STUDYING PROTEIN CONFORMATIONS FOR BIOMATERIAL OPTIMIZATION
As my undergraduate thesis project, I worked in KSask Lab under the Department of Materials Science and School of Biomedical Engineering. My work focused on studying how blood plasma proteins, apolipoprotein AI (apo-AI) and Fibrinogen underwent conformational changes upon adsorption to gold. The objective of this study is to characterize protein conformations of proteins to optimize surface topographies and ultimately minimize the coagulation cascade for blood-contacting devices. The final deliverable of my thesis can be accessed below.
Literature Review
Comparison of the different methodologies that can be used to study protein conformational changes.
Thesis Document
Final undergraduate thesis document studying the protein conformations of apolipoprotein-AI and fibrinogen upon adsorption to a gold surface.
Presentation
Slides used for the undergraduate thesis defence.